General objective
To provide updated knowledge and critical debates on different aspects of eosinophilic esophagitis, 3 decades after the description and characterization of the disease as a distinctive clinico-pathological syndrome.
The contents have been prepared based on the best evidence, and address a historical review of the disease by the authors of the original reports on it, an interactive presentation of complex clinical cases, aimed at highlighting the diagnostic and therapeutic difficulties that many patients still represent, and a conference on current advances in the knowledge of the disease and the most important aspects that must be addressed in the future for the best care of patients.
Specific objectives
To know the scientific and healthcare environment in which the concept of eosinophilic esophagitis as its own disease appeared.
To understand the difficulties associated with the paradigm shift that the description of this disease represented
To recognize the most important research groups over the past 3 decades in the development of knowledge about the disease
To know the different advances in the identification of cases, definition of diagnostic criteria and proposal of treatment alternatives.
To nderstand the differences in the clinical presentation of EoE in patients of different ages
To know the pathologies that require a differential diagnosis with EoE
To describe the decision process in selecting the most appropriate treatments for each patient based on particular characteristics.
To Understand the need for a multidisciplinary approach to EoE in complex cases.
To analyze the keys behind the growing epidemiology of EoE
To propose strategies to understand the growing impact that dysphagia and food impingement have for the patient and health systems from a multidimensional vision.
To presents advances in knowledge of the pathophysiology of the disease and how they could impact treatment.
To propose measures to improve diagnosis and optimize initial treatment of patients
To understand the complexity of maintaining treatment adherence in a chronic disease and propose ways to address it
To understand the approach to continued treatment in a chronic disease and analyze measures to accelerate the development of new therapy options
To know the current epidemiological characteristics of eosinophilic esophagitis, including its incidence, prevalence and temporal trends.
To identify the known risk factors for the development of EoE and the interaction between atopy, genes and the environment in its origin.
To discuss potential causes for the increase in EoE in industrialized countries and trends in emerging countries
To review the evidence on the natural history of the disease and its tendency to become chronic.
To learn about the effectiveness of the different therapies for the maintenance of remission in patients with EoE.
To Know the rates of abandonment of treatment and the risk factors for it
To discuss the need for universal maintenance therapy, based on the best available evidence.
To present the concept of EoE phenotypes and their potential value in predicting clinical course and therapeutic needs
To identify reasons for treating EoE patients and unmet needs
To identify new therapeutic targets for EoE
To present advanced drugs in development for EoE, including biologics and small molecules
To discuss the profile of patients who could be best candidates for these new therapies
